Multispecific antibody service

Monoclonal antibodies have become a critical and effective therapeutic approach in cancer treatment due to their specific targeting ability toward molecules. However, owing to the complex pathogenic mechanisms of cancer, monoclonal antibodies targeting a single point struggle to demonstrate sufficient therapeutic efficacy. In this context, bispecific antibodies have emerged.

多特异性抗体服务

Molecular format example

Bispecific antibodies bind to two or more different antigens, opening up new therapeutic applications that traditional monoclonal antibodies cannot achieve. They facilitate redirecting drugs to the local tumor, enhancing binding specificity, improving the accuracy of drug targeting to tumor cells, and reducing off-target toxicity. Mabnus Biotech's extensive experience in bispecific antibody projects allows us to design and express various forms of bispecific antibodies for our clients. Starting from hybridoma cell lines or antibody sequences, we can provide customized bispecific antibodies ranging from milligrams to grams.


Platform features
Easy
Easy

Complete sequence analysis quickly and efficiently to determine the subsequent antibody sequence

Unlimited species
Unlimited species

Efficient skeleton design, not limited to mouse, rabbit, human and other species

Team
Team

Sequence analysis, expression test, antibody indication, smooth process

Compatible
Compatible

Whether expressed in transient or stable cells, batches of stable recombinant antibodies are obtained without interference from animal sources

Data
Data

Complete antibody analysis, test, characterization data report

Service Content

Cycle

Project design
Project design

Preliminary investigation, communication and confirmation

1 day
Analysis sequence
Analysis sequence

Analysis antibody CDR framework

1-2 day
Vector construction
Vector construction

Determine the proper frame

1-2 day
Antibody effectiveness test
Antibody effectiveness test

The recombinant expression was analyzed by antibody characterization.

2-3周
Delivery
Delivery

Experimental report, recombinant antibody, modified sequence document

1 day
Case Show
Antibody A&B&C

Antibodies A, B and C are monoclonal antibodies specific to three targets respectively.

The sequence analysis of three antibodies was conducted to extract the variable region of the heavy and light chain. A and B antibodies were combined by Crossmab& KIH, and C antibody was transformed into scFv and fused at the C end of the heavy chain of B antibody.


Antibody A&B&C