Multiplexed selectivity screening of anti-GPCR antibodies
Multiplexed selectivity screening of anti-GPCR antibodies
2023-05-12
（DahlL,etal. SciAdv.2023）The G protein-coupled receptor (GPCR) superfamily is the largest family of human membrane proteins and drug targets, comprising approximately 750 memb...
Pyroptosis the GSDM family
Pyroptosis the GSDM family
2023-03-27
Members of the gasdermin (GSDM) family are widely expressed and may play tissue-specific roles. For 15 years, scientists have been trying to determine the structure and function of...
Known antibody sequence development again
Known antibody sequence development again
2023-03-15
Antibodies, also known as immunoglobulins (Ig), were first described in 1890. They are large, Y-shaped glycoproteins that the immune system uses to recognize and neutralize foreign...
Transport protein superfamily SLC
Transport protein superfamily SLC
2023-03-08
To survive and maintain normal function, cells must closely monitor and control intracellular substances. By allowing specific molecules such as metabolites and ions to pass throug...
Specific transcriptional coactivator YAP1
Specific transcriptional coactivator YAP1
2023-03-01
Yes-associated protein 1 (YAP1) is a transcriptional coactivator that is most prominently expressed in normal adult liver and biliary epithelial cells (BECs) during development . I...
Protein family FGF
Protein family FGF
2023-02-13
Fibroblast growth factor (FGF) is a broad-spectrum mitogen that acts as a polypeptide ligand in a paracrine or endocrine manner. FGF stimulates or maintains specific cellular funct...
FGF11: potential obesity target
FGF11: potential obesity target
2023-02-02
The fibroblast growth factor (FGF) 11 subfamily consists of FGF11, FGF12, FGF13, and FGF14. The FGF11 subfamily is independent of the other subfamilies, with its most notable chara...