Specific transcriptional coactivator YAP1
Specific transcriptional coactivator YAP1
2023-03-01
Yes-associated protein 1 (YAP1) is a transcriptional coactivator that is most prominently expressed in normal adult liver and biliary epithelial cells (BECs) during development . I...
Protein family FGF
Protein family FGF
2023-02-13
Fibroblast growth factor (FGF) is a broad-spectrum mitogen that acts as a polypeptide ligand in a paracrine or endocrine manner. FGF stimulates or maintains specific cellular funct...
FGF11: potential obesity target
FGF11: potential obesity target
2023-02-02
The fibroblast growth factor (FGF) 11 subfamily consists of FGF11, FGF12, FGF13, and FGF14. The FGF11 subfamily is independent of the other subfamilies, with its most notable chara...
FGF18：a therapeutic target for osteoarthritis
FGF18：a therapeutic target for osteoarthritis
2023-02-02
Fibroblast growth factor 18 (FGF18) belongs to the FGF8 subfamily and plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. It i...
FGF1: an antidiabetic potential drug target
FGF1: an antidiabetic potential drug target
2023-02-02
Fibroblast growth factor 1 ( FGF1 ) was discovered in 1979, and its molecular identity and properties were determined over the next decade. A series of studies beginning in 1989 li...
FGF19：Clinical value to be exploited
FGF19：Clinical value to be exploited
2023-02-02
The fibroblast growth factor 19 (FGF19) subfamily includes three proteins: FGF19, FGF21, and FGF23, which show activity on FGFR1c, 2c, 3c, and 4 receptors, but cannot bind to FGFR1...
FGF2: A myriad factor
FGF2: A myriad factor
2023-02-02
Fibroblast growth factor 2 (FGF2), also known as basic FGF (bFGF), is one of the earliest recognized members of the FGF family. As a ligand for FGFR1, FGFR2, FGFR3, and FGFR4, it p...