Structural basis for selectivity and antagonism in extracellular GPCR nanobodies
Structural basis for selectivity and antagonism in extracellular GPCR nanobodies
2024-06-12
BackgroundG protein-coupled receptors (GPCRs) are important therapeutic targets, but their complex structures pose challenges for effective drug design. Nanobodies (i.e., single-do...
Heart failure biomarkers NT-ProBNP and BNP
Heart failure biomarkers NT-ProBNP and BNP
2024-06-11
B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) both belong to the natriuretic peptide (NP) family. Concentrations of NT-proBNP and BNP i...
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
2024-06-07
BackgroundThe dendritic cell inhibitory receptor (DCIR) is a C-type lectin receptor selectively expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and n...
AggreProt: a web server for predicting and engineering aggregation pron eregions in proteins
AggreProt: a web server for predicting and engineering aggregation pron eregions in proteins
2024-06-06
BackgroundRecombinant proteins play a key role in many applications, including industrial biocatalysis and therapeutics. Despite recent advances in computational protein structure ...
The key factors in IgG1 secretion are CH-CL pairing and VL domain integrity
The key factors in IgG1 secretion are CH-CL pairing and VL domain integrity
2024-06-05
BackgroundThe CH1 domain of IgG antibodies controls antibody assembly and secretion through the endoplasmic reticulum protein quality control (ERQC) mechanism, mediated by the mole...
The introduction of ADC drug Payload
The introduction of ADC drug Payload
2024-06-04
Antibody-drug conjugates (ADCs) are a promising cancer treatment, capable of selectively delivering a cytotoxic payload to tumors while minimizing the severity of side effects . AD...
Two sided interferon IFNγ
Two sided interferon IFNγ
2024-06-03
IFNγ is a cytokine and the only member of the type II interferon family. It plays a crucial role in tissue homeostasis, immune and inflammatory responses, and tumor immunosurveilla...