The key factors in IgG1 secretion are CH-CL pairing and VL domain integrity
The key factors in IgG1 secretion are CH-CL pairing and VL domain integrity
2024-06-05
BackgroundThe CH1 domain of IgG antibodies controls antibody assembly and secretion through the endoplasmic reticulum protein quality control (ERQC) mechanism, mediated by the mole...
The introduction of ADC drug Payload
The introduction of ADC drug Payload
2024-06-04
Antibody-drug conjugates (ADCs) are a promising cancer treatment, capable of selectively delivering a cytotoxic payload to tumors while minimizing the severity of side effects . AD...
Two sided interferon IFNγ
Two sided interferon IFNγ
2024-06-03
IFNγ is a cytokine and the only member of the type II interferon family. It plays a crucial role in tissue homeostasis, immune and inflammatory responses, and tumor immunosurveilla...
Cancer therapy with antibodies
Cancer therapy with antibodies
2024-05-24
BackgroundThe greatest challenge in cancer treatment is eradicating cancer cells with minimal loss of normal cells. To address this challenge, targeted therapies have been develope...
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
2024-05-23
BackgroundBispecific antibodies are artificial molecules that fuse the two distinct antigen-binding sites of a monoclonal antibody into a single entity. They have emerged as a prom...
The stem cell factor receptor CD117
The stem cell factor receptor CD117
2024-05-22
CD117, also known as c-Kit, KIT or stem cell factor (SCF) receptor, is a type III tyrosine protein kinase that plays an important role in cell survival and proliferation, hematopoi...
Interleukin-7 receptor alpha subunit CD127
Interleukin-7 receptor alpha subunit CD127
2024-05-21
CD127 is the alpha subunit of the interleukin-7 receptor (IL-7Rα). It also functions as a receptor for thymic stromal lymphopoietin (TSLP). CD127 regulates the proliferation, diffe...