Single domain antibodies as therapeutics for solid tumor treatment
Single domain antibodies as therapeutics for solid tumor treatment
2024-08-13
BackgroundTraditional cancer treatments, including surgery, chemotherapy, and radiotherapy, are often poorly targeted and, while killing tumor cells, can damage normal cells, resul...
Lipid control protein PCSK9
Lipid control protein PCSK9
2024-08-12
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted serine protease primarily synthesized in the liver. It primarily binds to the low-density lipoprotein receptor (...
Human epidermal growth factor receptor HER3
Human epidermal growth factor receptor HER3
2024-08-09
HER3 is a human epidermal growth factor receptor (ERBB3). HER3 protein belongs to the ErbB/HER receptor tyrosine kinase (RTK) family and is expressed in many types of tumors. HER3 ...
rhIL-7-hyFc improves the efficacy of CAR-T cells in the treatment of solid tumors
rhIL-7-hyFc improves the efficacy of CAR-T cells in the treatment of solid tumors
2024-08-08
BackgroundGenetically engineered T cells expressing chimeric antigen receptors (CARs) are an emerging cancer immunotherapy. So far, the US Food and Drug Administration (FDA) has ap...
Thymic stromal lymphopoietin TSLP
Thymic stromal lymphopoietin TSLP
2024-08-08
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils...
ANV419 has a strong ability to stimulate CD8-T cells and natural killer cells
ANV419 has a strong ability to stimulate CD8-T cells and natural killer cells
2024-08-07
BackgroundInterleukin-2 (IL-2) is an agonist that plays a crucial role in cancer immunotherapy. High-dose recombinant IL-2 (Proleukin®/aldesleukin) is the first approved cytokine-b...
Strategies to overcome the challenges of low or no expression of heterologous proteins in Escherichia coli
Strategies to overcome the challenges of low or no expression of heterologous proteins in Escherichia coli
2024-08-07
BackgroundProtein expression is a critical process in a wide range of biological systems. Escherichia coli, a microbial host widely used in industrial catalysis and healthcare, oft...