The immune checkpoint molecule B7H3
The immune checkpoint molecule B7H3
2024-10-18
B7H3, also known as CD276, is a member of the B7 family of immune checkpoint proteins. This immune checkpoint molecule is selectively expressed by tumor cells and immune cells with...
Comparative study of the exploitability of full-length antibody, fragment, and bispecific formats
Comparative study of the exploitability of full-length antibody, fragment, and bispecific formats
2024-10-17
BackgroundEngineered antibody formats, such as fragment antibodies and bispecific antibodies, may offer improved therapeutic efficacy compared to traditional full-length monoclonal...
A single-chain fab derived drug conjugate for HER2 specific delivery
A single-chain fab derived drug conjugate for HER2 specific delivery
2024-10-16
BackgroundAntibody-drug conjugates (ADCs) offer advantages such as targeted specificity, potent anti-cancer effects, and a long circulation half-life. However, ADCs also have limit...
The inflammatory itch cytokine IL-31
The inflammatory itch cytokine IL-31
2024-10-15
Interleukin-31 (IL31) is a proinflammatory cytokine and a key member of the IL-6 family of cytokines. IL31 has been implicated in a variety of atopic diseases, such as atopic derma...
Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
2024-10-14
Antibodies can be synthesized through a variety of strategies, starting with polyclonal antibodies produced through animal immunization, followed by monoclonal antibodies produced ...
Hepatocyte growth factor receptor c-MET
Hepatocyte growth factor receptor c-MET
2024-10-11
c-MET, also known as MET or hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase belonging to the MET family. Hepatocyte growth factor (HGF) is a specific ligand...
The role of glycosylation in cancer and clinical therapy
The role of glycosylation in cancer and clinical therapy
2024-10-09
BackgroundGlycosylation is a key protein modification in vivo, playing an important role in regulating various biological functions by influencing protein folding, transport, and l...