The unique cadherin CDH17
The unique cadherin CDH17
2024-09-20
CDH17 is a cadherin protein belonging to a subclass of the 7D-cadherin family. Its primary function is cell-cell adhesion, which may be involved in tumorigenesis. The adhesion mech...
Improving Protein Expression, Stability, and Function with ProteinMPNN
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024-09-18
BackgroundNatural proteins are highly optimized for function but are often difficult to produce at scales suitable for biotechnological applications due to poor expression in heter...
The Effects of Codon Usage on Protein Structure and Folding
The Effects of Codon Usage on Protein Structure and Folding
2024-09-18
BackgroundThe increasing sophistication of machine learning algorithms has enabled the prediction of protein structure based solely on amino acid sequence, and these methods have h...
Developability considerations for bispecific and multispecific antibodies
Developability considerations for bispecific and multispecific antibodies
2024-09-12
BackgroundBispecific antibodies (bsAbs) and multispecific antibodies (msAbs) encompass a wide range of formats and can simultaneously bind multiple epitopes, unlocking mechanisms t...
The cell adhesion molecule ICAM1
The cell adhesion molecule ICAM1
2024-09-11
ICAM-1, also known as CD54, is a cell surface glycoprotein. It acts as a biosensor, transducing outside-in signals through its cytoplasmic domain, which binds to the extracellular ...
The inhibitory receptor TIGIT
The inhibitory receptor TIGIT
2024-09-10
TIGIT is a T cell immunoreceptor with both Ig and ITIM domains. It is an inhibitory receptor, also known as VSIG9 and VSTM3. It binds with high affinity to the poliovirus receptor ...
Suitable conditions were selected for eukaryotic protein expression
Suitable conditions were selected for eukaryotic protein expression
2024-09-09
Eukaryotic mammalian expression systems play a crucial role in protein expression technology. Mammalian protein production has become the standard for the production of state-of-th...