Treatment of obesity and metabolic diseases target GLP1R
Treatment of obesity and metabolic diseases target GLP1R
2024-10-22
The glucagon-like peptide 1 receptor (GLP1R) is an important member of the G protein-coupled receptor (GPCR) family. It specifically interacts with GLP-1, a key hormone that plays ...
How to isolate channel-forming membrane proteins using the E.coli expression system
How to isolate channel-forming membrane proteins using the E.coli expression system
2024-10-21
BackgroundRecombinant expression, isolation, and characterization of perforins are among the most common strategies used to understand their membrane permeability properties. One t...
The immune checkpoint molecule B7H3
The immune checkpoint molecule B7H3
2024-10-18
B7H3, also known as CD276, is a member of the B7 family of immune checkpoint proteins. This immune checkpoint molecule is selectively expressed by tumor cells and immune cells with...
Comparative study of the exploitability of full-length antibody, fragment, and bispecific formats
Comparative study of the exploitability of full-length antibody, fragment, and bispecific formats
2024-10-17
BackgroundEngineered antibody formats, such as fragment antibodies and bispecific antibodies, may offer improved therapeutic efficacy compared to traditional full-length monoclonal...
A single-chain fab derived drug conjugate for HER2 specific delivery
A single-chain fab derived drug conjugate for HER2 specific delivery
2024-10-16
BackgroundAntibody-drug conjugates (ADCs) offer advantages such as targeted specificity, potent anti-cancer effects, and a long circulation half-life. However, ADCs also have limit...
The inflammatory itch cytokine IL-31
The inflammatory itch cytokine IL-31
2024-10-15
Interleukin-31 (IL31) is a proinflammatory cytokine and a key member of the IL-6 family of cytokines. IL31 has been implicated in a variety of atopic diseases, such as atopic derma...
Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
2024-10-14
Antibodies can be synthesized through a variety of strategies, starting with polyclonal antibodies produced through animal immunization, followed by monoclonal antibodies produced ...