Skin inflammation treatment target IL36R
Skin inflammation treatment target IL36R
2024-11-04
IL-36 belongs to the IL-1 superfamily of cytokines and is composed of three agonists (IL-36α, IL-36β, and IL-36γ) and one antagonist (IL-36Ra). IL-36R, also known as IL1RL2, IL-1Rr...
Alzheimer disease therapeutic target TREM2
Alzheimer disease therapeutic target TREM2
2024-11-01
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor of the immunoglobulin superfamily, primarily expressed on microglia in the brain and macrophage...
Introduction to proximity marking technology
Introduction to proximity marking technology
2024-10-30
Protein-protein interactions (PPIs) play a crucial role in biological function, participating in cellular biological processes such as cell cycle regulation and signal transduction...
Proximity labeling in mammalian cells with TurboID and split-TurboID
Proximity labeling in mammalian cells with TurboID and split-TurboID
2024-10-29
TurboID is an engineered biotin ligase that uses ATP to convert biotin into biotin-AMP, an active intermediate that covalently labels neighboring proteins. Optimized through direct...
Small cell lung cancer treatment target DLL3
Small cell lung cancer treatment target DLL3
2024-10-28
Delta-Like Ligand 3 (DLL3) is a member of the Delta-like ligand (DLL) family. It is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and other n...
Interleukin-27
Interleukin-27
2024-10-27
Interleukin-27 (IL27) is a cytokine that has significantly different effects on immune responses. IL27 stimulates T cells to promote the secretion of the anti-inflammatory cytokine...
T-cells costimulate the immune checkpoint molecule 4-1BB
T-cells costimulate the immune checkpoint molecule 4-1BB
2024-10-25
4-1BB is a T cell co-stimulatory immune checkpoint molecule also known as CD137 or TNF receptor superfamily member 9 (TNFRSF9). The interaction between 4-1BB and its primary ligand...