Optimized development of therapeutic anti-oxMIF antibodies based on computer and in vitro tools
Optimized development of therapeutic anti-oxMIF antibodies based on computer and in vitro tools
2025-01-06
BackgroundRigorous assessment of the developability of antibodies is crucial for optimizing drug candidates before entering clinical studies. Recent advances in tools for predictin...
Consideration of recombinant expression of His small label fusion protein
Consideration of recombinant expression of His small label fusion protein
2025-01-03
BackgroundThe Histidine tag (polyhistidine tag) is a commonly used protein tag used for protein expression, purification, and detection in biochemistry and molecular biology. It co...
T-cell costimulatory molecule OX40
T-cell costimulatory molecule OX40
2025-01-02
OX40 is a T cell co-stimulatory molecule and a member of the tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134. OX40 plays a crucial co-stimulatory...
Trophoblast cell surface antigen TROP2
Trophoblast cell surface antigen TROP2
2024-12-31
Trophoblast cell surface antigen 2 (TROP2), also known as tumor-associated calcium signal sensor 2 (TACSTD2), is overexpressed in a range of solid tumors and significantly impacts ...
Tissue factor pathway inhibitor TFPI
Tissue factor pathway inhibitor TFPI
2024-12-30
Tissue factor pathway inhibitor ( TFPI ) is an alternatively spliced anticoagulant protein that primarily inhibits the initial stage of coagulation, preceding thrombin generation. ...
Advancements and challenges in immunocytokines
Advancements and challenges in immunocytokines
2024-12-27
BackgroundImmunocytokines utilize targeted antibodies to concentrate cytokines at tumor sites and have shown potential advantages, such as prolonged cytokine half-life, reduced adv...
The angiogenin VEGFA
The angiogenin VEGFA
2024-12-25
Vascular endothelial growth factor (VEGF) is a homodimeric vasoactive glycoprotein and a key mediator of angiogenesis. The VEGF family consists of five separate gene products: VEGF...