Nectin-4 is a novel target of the ADC circuit
Nectin-4 is a novel target of the ADC circuit
2025-01-10
Nectin-4, also known as poliovirus receptor-associated protein 4, is closely associated with tumor growth, angiogenesis, metastasis, and recurrence. Due to its target-specific expr...
The cadherin CDH6
The cadherin CDH6
2025-01-09
CDH6, also known as fetal kidney cadherin or K-cadherin, is involved in the morphogenesis and development of the embryonic kidney, driving the mesenchymal-epithelial differentiatio...
Key differences and limitations of antibody numbering schemes
Key differences and limitations of antibody numbering schemes
2025-01-07
Background           The complementarity-determining regions (CDRs) of antibodies are the most diverse regions in terms of sequence and structural cha...
Optimized development of therapeutic anti-oxMIF antibodies based on computer and in vitro tools
Optimized development of therapeutic anti-oxMIF antibodies based on computer and in vitro tools
2025-01-06
BackgroundRigorous assessment of the developability of antibodies is crucial for optimizing drug candidates before entering clinical studies. Recent advances in tools for predictin...
Consideration of recombinant expression of His small label fusion protein
Consideration of recombinant expression of His small label fusion protein
2025-01-03
BackgroundThe Histidine tag (polyhistidine tag) is a commonly used protein tag used for protein expression, purification, and detection in biochemistry and molecular biology. It co...
T-cell costimulatory molecule OX40
T-cell costimulatory molecule OX40
2025-01-02
OX40 is a T cell co-stimulatory molecule and a member of the tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134. OX40 plays a crucial co-stimulatory...
Trophoblast cell surface antigen TROP2
Trophoblast cell surface antigen TROP2
2024-12-31
Trophoblast cell surface antigen 2 (TROP2), also known as tumor-associated calcium signal sensor 2 (TACSTD2), is overexpressed in a range of solid tumors and significantly impacts ...