Tumor specific marker CD248
Tumor specific marker CD248
2025-05-15
Endosialin, also known as tumor endothelial marker 1 (TEM1) or CD248, is a single-transmembrane glycoprotein with a C-type lectin-like domain. Endosialin is expressed in cancer-ass...
Immune checkpoint protein CD200
Immune checkpoint protein CD200
2025-05-14
CD200 is an OX-2 membrane glycoprotein, also known as MOX1 and MOX2. It can synergistically stimulate T cell proliferation and may regulate myeloid cell activity in various tissues...
The multiverse of CD46 and oncologic interactions
The multiverse of CD46 and oncologic interactions
2025-05-13
BackgroundCD46 is a membrane cofactor protein (MCP) that originally regulates complement activation in host cells. It is expressed in four major isoforms in all nuclear cells and i...
The anaphylatoxin receptor C5AR1
The anaphylatoxin receptor C5AR1
2025-05-08
The complement system plays a crucial role in the innate immune response against invading pathogens. The complement fragment C5a is one of its key effector components, activating t...
Osteoclast differentiation and activation factor RANKL
Osteoclast differentiation and activation factor RANKL
2025-05-07
Receptor for activator of nuclear factor kappa-B (RANKL), also known as OPGL (CD254), is a member of the tumor necrosis factor ligand superfamily, member 11 (TNFSF11). It is a fact...
CD30 is a therapeutic target for lymphoma
CD30 is a therapeutic target for lymphoma
2025-05-06
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30 or Ki-1 antigen, is a receptor for TNFSF8/CD30L. It may play a role in the regulation of cell grow...
Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
2025-05-05
BackgroundIgG antibodies, essential for the normal functioning of the immune system, recognize antigens and neutralize pathogens through their Fab regions. Their Fc regions bind to...