The chemokine receptor CXCR4
The chemokine receptor CXCR4
2025-03-12
CXCR4, also known as CD184, is a CXC chemokine receptor type 4, a class A G protein-coupled receptor (GPCR). It is activated by chemotactic ligands and participates in regulating h...
Immune Sentinel TLR4
Immune Sentinel TLR4
2025-03-11
Toll-like receptor 4 (TLR4) is a transmembrane receptor that plays a key role in the innate immune system. It recognizes pathogen-associated molecular patterns (PAMPs) and damage-a...
YAbS：The Antibody Society’s antibody therapeutics database
YAbS：The Antibody Society’s antibody therapeutics database
2025-03-10
BackgroundTherapeutic antibodies have garnered significant attention in recent years for their precise ability to target specific diseases. As these molecules become increasingly i...
The pleiotropic cytokine IL9
The pleiotropic cytokine IL9
2025-03-07
Interleukin 19 (IL19), a member of the IL-2RγC chain family, is a pleiotropic cytokine that regulates the functions of various cells. Originally identified as a growth factor for T...
Dual inhibition of a novel bispecific antibody CDX-622
Dual inhibition of a novel bispecific antibody CDX-622
2025-03-05
BackgroundBiologically based therapies targeting cytokine pathways have demonstrated significant clinical benefit in a number of inflammatory and autoimmune diseases. Many of these...
The target of tumor immunotherapy is MUC1
The target of tumor immunotherapy is MUC1
2025-03-03
Mucin1 (MUC1, also known as EMA, MCD, PEM, PUM, KL-6, and MAM6) is a large protein. It is the most recognizable transmembrane protein in the mucin family and has a heavily glycosyl...
De novo designed proteins neutralize lethal snake venom toxins
De novo designed proteins neutralize lethal snake venom toxins
2025-02-25
BackgroundSnakebite envenomation is a devastating and neglected tropical disease that causes severe complications and disability in humans. Three-finger toxin (3FTx), the highly to...