The cannabinoid receptor CNR1
The cannabinoid receptor CNR1
2025-04-15
Cannabinoid receptor 1 (CNR1), also known as CB1 or CBR, is a G protein-coupled receptor (GPCR) for endocannabinoids (eCBs) and has therapeutic potential in diseases such as pain, ...
Inactivated tyrosine protein kinase PTK7
Inactivated tyrosine protein kinase PTK7
2025-04-14
Inactive protein tyrosine kinase 7 (PTK7), also known as colon cancer kinase 4 (CCK-4), is a component of both the non-canonical (also known as Wnt/planar cell polarity signaling) ...
A novel target for ADC tumor therapy LRRC15
A novel target for ADC tumor therapy LRRC15
2025-04-09
An abundant fibrotic stroma is a hallmark of most solid tumors, and stromal activation promotes tumorigenesis, therapeutic resistance, and metastatic dissemination of cancer cells....
T-cell activation inhibitor VISTA
T-cell activation inhibitor VISTA
2025-04-08
V-type immunoglobulin domain-containing inhibitor of T-cell activation (VISTA), also known as VISR, is a member of the B7 family. It is an immunomodulatory receptor that inhibits T...
Bispecific antibody heavy and light chain matching design
Bispecific antibody heavy and light chain matching design
2025-04-07
BackgroundThe correct assembly of a four-chain IgG-like bispecific composed of two different light and heavy chains requires the formation of three heterodimer interfaces: one form...
ADAM9 is a new target for ADC anticancer therapy
ADAM9 is a new target for ADC anticancer therapy
2025-04-03
A disintegrin and metalloproteinase 9 (ADAM9), also known as MDC9 or meltrin-γ, is a metalloproteinase that cleaves and releases numerous molecules important in tumorigenesis and a...
Allergic trigger IgE
Allergic trigger IgE
2025-04-02
T2 inflammation is propagated by several key cell types, including T helper 2 (Th2) cells, eosinophils, mast cells, and B cells. Immunoglobulin E (IgE), produced by B cells, is a k...