Recombinant IgA shape the intestinal microbiota
Recombinant IgA shape the intestinal microbiota
2025-09-24
PrefaceIgA mediates microbial homeostasis in the intestinal mucosa. Microbial-reactive IgA is produced in the gut through both T-cell-independent and T-cell-dependent pathways , pl...
The melanogenic enzyme GPNMB
The melanogenic enzyme GPNMB
2025-09-23
GPNMB is a transmembrane glycoprotein and melanin-producing enzyme, also known as hematopoietic growth factor-induced neurokinin type 1. As an immunosuppressive molecule, GPNMB pro...
The serine protease HTRA1
The serine protease HTRA1
2025-09-22
The serine protease HTRA1 has multiple targets, including extracellular matrix proteins such as fibronectin. Fibronectin fragments generated by HTRA1 further induce synoviocytes to...
The chemokine CXCL10
The chemokine CXCL10
2025-09-19
Inflammatory chemokines CXCLs (CXCL9, CXCL10, CXCL11, etc.) are primarily induced by interferon (IFN)-γ and share a dedicated chemokine receptor, CXC chemokine receptor 3 (CXCR3). ...
Lectin pathway related serine protease MASP
Lectin pathway related serine protease MASP
2025-09-18
The complement system is an important component of innate immunity and can be activated through three pathways: the classical pathway (CP), the alternative pathway (AP), and the le...
Matrix metalloproteinase MMP9
Matrix metalloproteinase MMP9
2025-09-17
Matrix metalloproteinase-9 (MMP9) can specifically degrade type IV collagen and plays an important role in local proteolysis of the extracellular matrix and leukocyte migration. Du...
Prolactin receptor PRLR
Prolactin receptor PRLR
2025-09-16
Prolactin receptor (PRLR) acts as a pro-survival factor on sperm by inhibiting sperm maturation by inhibiting SRC kinase activation and stimulating AKT. PRL/PRLR signaling promotes...