The Wnt pathway activates the receptor family FZD
2025-12-02
The FZD receptor family consists of seven transmembrane receptors, structurally belonging to the G protein-coupled receptor (GPCR) superfamily, but their signal transduction mechan...
The tyrosine protein kinase PDGFRA
2025-12-01
Platelet-derived growth factor receptor α (PDGFRA), also known as CD140a, is a tyrosine protein kinase (TK) that acts as the cell surface receptor for PDGFA, PDGFB, and PDGFC, play...
Regulatory T-cell activation regulatory receptor LRRC32
2025-12-01
Glycoprotein-A repetitions predominant (GARP), also known as LRRC32, is a potential docking receptor for transforming growth factor β1 (LTGF-β1) and is expressed on the surface of ...
Regulatory target of neuronal regeneration and survival RGMA
2025-11-25
RGMA plays multiple functions in the developmental and adult nervous systems. It regulates cephalane tube closure, inhibits neurite growth and cortical neuronal branching, and prom...
Transmembrane serine threonine kinases TGFBR1 and TGFBR2
2025-11-25
Transmembrane serine/threonine kinases TGFBR1 and TGFBR2 are non-pleiotropic receptors for TGF-β cytokines (TGFB1, TGFB2, and TGFB3). They transduce TGFB1, TGFB2, and TGFB3 signals...
The target for regulating melanin production TYRP1
2025-11-24
Tyrosinase-associated protein 1 (TYPR1), also known as CAS2, TYRP, TYRRP, or TRP1, plays an important role in melanin biosynthesis and can regulate or influence the type of melanin...
The osteogenesis inhibitor SOST
2025-11-24
Sclerostin (SOST) is a negative regulator of bone growth, acting by inhibiting Wnt signaling and bone formation. SOST regulates bone metabolism and is also expressed in cardiovascu...