The target of Signal Regulatory Protein Alpha SIRPα
The target of Signal Regulatory Protein Alpha SIRPα
2025-09-03
Regulatory Protein Alpha ( SIRPA) is a type I transmembrane protein whose core function is to transmit the "don't eat me" signal through the SIRP A -CD47 axis, inhibiting macrophag...
The target of Sialic acid-binding Ig-like lectin 8 SIGLEC8
The target of Sialic acid-binding Ig-like lectin 8 SIGLEC8
2025-09-02
Sialic acid-binding immunoglobulin-like lectin 8 ( SIGLEC8) is a transmembrane protein that primarily functions as an inhibitory receptor, acting like a brake on the immune system....
Protein antibody SPR enabling new drug development
Protein antibody SPR enabling new drug development
2025-09-01
BackgroundThe emergence and rapid spread of multidrug-resistant Botrytis cinerea poses a significant challenge to the quality and safety of agricultural products and the efficient ...
Deep learning guided design of dynamic proteins
Deep learning guided design of dynamic proteins
2025-08-29
BackgroundDeep learning has greatly advanced the design of highly stable static protein structures. However, mimicking the controllable conformational dynamics of natural switch pr...
The target of Leptin receptor LEPR
The target of Leptin receptor LEPR
2025-08-29
LEPR expression distributionLEPR isoform A is expressed in fetal liver, hematopoietic tissue, and the choroid plexus. In adults, its highest expression is in the heart, liver, smal...
Nuclear regulator of cell fate Notch3
Nuclear regulator of cell fate Notch3
2025-08-26
The neurogenic locus Notch homolog 3 (Notch3) regulates cell fate as a receptor for the membrane-bound ligands Jagged1, Jagged2, and Delta1. Upon ligand activation via the released...
The axon guidance factor SEMA4D
The axon guidance factor SEMA4D
2025-08-25
Axon guidance agent 4D (SEMA4D), also known as CD100, belongs to the semaphorin IV subfamily. It is a cell surface receptor for PLXNB1 and PLXNB2 and plays an important role in int...