Type I interferon targets IFNA1 and IFNB
Type I interferon targets IFNA1 and IFNB
2025-10-09
Interferon (IFN)-mediated antiviral responses are central to host defense against viral infection. First discovered in the 1950s and named for their ability to interfere with viral...
Recombinant IgA shape the intestinal microbiota
Recombinant IgA shape the intestinal microbiota
2025-09-24
PrefaceIgA mediates microbial homeostasis in the intestinal mucosa. Microbial-reactive IgA is produced in the gut through both T-cell-independent and T-cell-dependent pathways , pl...
The melanogenic enzyme GPNMB
The melanogenic enzyme GPNMB
2025-09-23
GPNMB is a transmembrane glycoprotein and melanin-producing enzyme, also known as hematopoietic growth factor-induced neurokinin type 1. As an immunosuppressive molecule, GPNMB pro...
The serine protease HTRA1
The serine protease HTRA1
2025-09-22
The serine protease HTRA1 has multiple targets, including extracellular matrix proteins such as fibronectin. Fibronectin fragments generated by HTRA1 further induce synoviocytes to...
The chemokine CXCL10
The chemokine CXCL10
2025-09-19
Inflammatory chemokines CXCLs (CXCL9, CXCL10, CXCL11, etc.) are primarily induced by interferon (IFN)-γ and share a dedicated chemokine receptor, CXC chemokine receptor 3 (CXCR3). ...
Lectin pathway related serine protease MASP
Lectin pathway related serine protease MASP
2025-09-18
The complement system is an important component of innate immunity and can be activated through three pathways: the classical pathway (CP), the alternative pathway (AP), and the le...
Matrix metalloproteinase MMP9
Matrix metalloproteinase MMP9
2025-09-17
Matrix metalloproteinase-9 (MMP9) can specifically degrade type IV collagen and plays an important role in local proteolysis of the extracellular matrix and leukocyte migration. Du...