The target of Leptin receptor LEPR
The target of Leptin receptor LEPR
2025-08-29
LEPR expression distributionLEPR isoform A is expressed in fetal liver, hematopoietic tissue, and the choroid plexus. In adults, its highest expression is in the heart, liver, smal...
Nuclear regulator of cell fate Notch3
Nuclear regulator of cell fate Notch3
2025-08-26
The neurogenic locus Notch homolog 3 (Notch3) regulates cell fate as a receptor for the membrane-bound ligands Jagged1, Jagged2, and Delta1. Upon ligand activation via the released...
The axon guidance factor SEMA4D
The axon guidance factor SEMA4D
2025-08-25
Axon guidance agent 4D (SEMA4D), also known as CD100, belongs to the semaphorin IV subfamily. It is a cell surface receptor for PLXNB1 and PLXNB2 and plays an important role in int...
Impact of antibody Fc engineering on translational pharmacology and safety
Impact of antibody Fc engineering on translational pharmacology and safety
2025-08-18
BackgroundThe Fc region of IgG isotype therapeutic monoclonal antibodies is often engineered to optimize their pharmacology and pharmacokinetic (PK) properties, with safety al...
The target of Fibroblast growth factor receptor2 FGFR2
The target of Fibroblast growth factor receptor2 FGFR2
2025-08-15
Fibroblast growth factor receptor 2 (FGFR2) is an important transmembrane tyrosine kinase receptor that plays a key role in regulating cell proliferation, differentiation, migratio...
The angiogenesis regulator Notch1
The angiogenesis regulator Notch1
2025-08-15
Neurogenic locus Notch homolog 1 (Notch1), also known as TAN1, acts as a receptor for the membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2), and Delta-1 (DLL1), regulating ce...
Vascular endothelial growth factor receptor VEGFR2
Vascular endothelial growth factor receptor VEGFR2
2025-08-14
Vascular endothelial growth factor receptor 2 (VEGFR2) is a tyrosine protein kinase, also known as fetal liver kinase 1 (FLK-1).Kinase insert domain receptor (KDR). VEGFR2 serves a...