A comprehensive antigen-antibody complex database unlocking insights into interaction interface
A comprehensive antigen-antibody complex database unlocking insights into interaction interface
2025-06-04
BackgroundAntibodies are essential components of the immune system and have a wide range of biomedical applications. Elucidating the complex interactions between antibodies and ant...
DKK1 is the core accomplicker of tumor immune escape
DKK1 is the core accomplicker of tumor immune escape
2025-06-02
DKK1 is a canonical Wnt signaling inhibitor that is overexpressed in many cancers and is often associated with poor clinical outcomes. DKK1 antagonizes canonical Wnt signaling by i...
Macrophage activation marker CD163
Macrophage activation marker CD163
2025-05-27
Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is a macrophage-specific receptor that plays a key role in clearing hemoglobin released during hemolysis and preventing...
AbSet: A Standardized Data Set of Antibody Structures for Machine Learning Applications
AbSet: A Standardized Data Set of Antibody Structures for Machine Learning Applications
2025-05-26
BackgroundMachine learning algorithms have played a fundamental role in the development of therapeutic antibodies by training on sequence and/or structural datasets. However, struc...
Target of treatment for acute myeloid leukemia FLT3
Target of treatment for acute myeloid leukemia FLT3
2025-05-22
The receptor tyrosine kinase FLT3, also known as stem cell tyrosine kinase 1 (STK-1), fetal liver kinase-2 (FLK-2), and CD135, serves as the cell surface receptor for the cytokine ...
Myeloid inhibitory C-type lectin receptor CLEC12A
Myeloid inhibitory C-type lectin receptor CLEC12A
2025-05-21
C-type lectin domain family 12 member A (CLEC12A), also known as C-type lectin-like molecule-1 (CLL-1), myeloid inhibitory C-type lectin-like receptor (MICL) , killer cell lectin-l...
High-throughput strategies for monoclonal antibody screening: advances and challenges
High-throughput strategies for monoclonal antibody screening: advances and challenges
2025-05-20
BackgroundAntibodies with high affinity and specificity, obtained through high-throughput screening and rapid production, are crucial to the contemporary biomedical industry. Tradi...