CD37 as a Therapeutic Target for Acute Myeloid Leukemia
CD37 as a Therapeutic Target for Acute Myeloid Leukemia
2025-05-16
CD37 is a tetraspanin protein prominently expressed on the surface of B cells. It plays a crucial role in regulating B cell survival, shaping immune responses, and facilitating imm...
Alarm cytokine IL1A
Alarm cytokine IL1A
2025-05-15
Interleukin-1α (IL1A) is a major alarmin cytokine that triggers and enhances inflammatory responses. It plays a crucial role in inflammation and bridges the innate and adaptive imm...
Tumor specific marker CD248
Tumor specific marker CD248
2025-05-15
Endosialin, also known as tumor endothelial marker 1 (TEM1) or CD248, is a single-transmembrane glycoprotein with a C-type lectin-like domain. Endosialin is expressed in cancer-ass...
Immune checkpoint protein CD200
Immune checkpoint protein CD200
2025-05-14
CD200 is an OX-2 membrane glycoprotein, also known as MOX1 and MOX2. It can synergistically stimulate T cell proliferation and may regulate myeloid cell activity in various tissues...
The multiverse of CD46 and oncologic interactions
The multiverse of CD46 and oncologic interactions
2025-05-13
BackgroundCD46 is a membrane cofactor protein (MCP) that originally regulates complement activation in host cells. It is expressed in four major isoforms in all nuclear cells and i...
The anaphylatoxin receptor C5AR1
The anaphylatoxin receptor C5AR1
2025-05-08
The complement system plays a crucial role in the innate immune response against invading pathogens. The complement fragment C5a is one of its key effector components, activating t...
Osteoclast differentiation and activation factor RANKL
Osteoclast differentiation and activation factor RANKL
2025-05-07
Receptor for activator of nuclear factor kappa-B (RANKL), also known as OPGL (CD254), is a member of the tumor necrosis factor ligand superfamily, member 11 (TNFSF11). It is a fact...