Receptor-ligand interactions for optimized endocytosis in targeted therapies
Receptor-ligand interactions for optimized endocytosis in targeted therapies
2025-02-24
BackgroundReceptor-mediated endocytosis plays a crucial role in the success of numerous therapeutics and remains central to advancing drug development. The process begins with liga...
B-lymphocyte antigen CD20
B-lymphocyte antigen CD20
2025-02-21
B-lymphocyte antigen (CD20), also known as MS4A1, plays a role in regulating cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. CD20 ...
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
2025-02-20
BackgroundThe mucin O-glycan sialylTn antigen (sTn, Neu5Acα2-6GalNAcα1-O-Ser/Thr) is an antigen associated with diverse cancer types and is generally associated with a higher risk ...
Engineered ipilimumab variants that bind human and mouse CTLA-4
Engineered ipilimumab variants that bind human and mouse CTLA-4
2025-02-18
BackgroundTesting candidate monoclonal antibody therapeutics in preclinical models is a critical step in drug development. Identifying antibody therapeutic candidates that bind to ...
The glucose regulatory receptor GIPR
The glucose regulatory receptor GIPR
2025-02-17
The gastric inhibitory peptide receptor (GIPR) is a receptor for glucose-dependent insulinotropic polypeptide (GIP) and belongs to the G protein-coupled receptor (GPCR) family. The...
T-cell immunomodulatory factor TIM3
T-cell immunomodulatory factor TIM3
2025-02-14
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3), also known as HAVCR2, is a member of the TIM family. It participates in regulating both innate and adaptive immu...
Therapeutic target of inflammatory bowel disease TL1A
Therapeutic target of inflammatory bowel disease TL1A
2025-02-10
TL1A is a member of the tumor necrosis factor ligand superfamily, member 15 (TNFSF15), also known as TL1 and VEGI. DcR3 is a functional ligand for TL1A, which plays an important ro...