The pleiotropic cytokine TGFB
The pleiotropic cytokine TGFB
2025-04-24
Transforming growth factor β (TGF - β, TGFB) is a multifunctional cytokine. TGF-β signaling is a key pathway in embryogenesis, tissue homeostasis, and cancer progression. TGF-β inc...
MSLN is the target of solid tumor treatment
MSLN is the target of solid tumor treatment
2025-04-22
Mesothelin (MSLN) is a cell-surface-bound glycosylphosphatidylinositol (GPI)-anchored protein. The membrane-anchored form may play a role in cell adhesion. Also known as megakaryoc...
Engineering IgG antibodies for intracellular targeting and drug delivery
Engineering IgG antibodies for intracellular targeting and drug delivery
2025-04-21
BackgroundMaking immunoglobulin G (IgG) antibodies autonomously internalize and localize to the cytoplasm of target cells (termed cytoplasmic-penetrating antibodies, CTs) is challe...
Bladder Cancer Treatment Target FGFR3
Bladder Cancer Treatment Target FGFR3
2025-04-16
Fibroblast growth factor receptor 3 (FGFR3) is a tyrosine protein kinase that acts as a cell surface receptor for fibroblast growth factor and is involved in regulating cell prolif...
The cannabinoid receptor CNR1
The cannabinoid receptor CNR1
2025-04-15
Cannabinoid receptor 1 (CNR1), also known as CB1 or CBR, is a G protein-coupled receptor (GPCR) for endocannabinoids (eCBs) and has therapeutic potential in diseases such as pain, ...
Inactivated tyrosine protein kinase PTK7
Inactivated tyrosine protein kinase PTK7
2025-04-14
Inactive protein tyrosine kinase 7 (PTK7), also known as colon cancer kinase 4 (CCK-4), is a component of both the non-canonical (also known as Wnt/planar cell polarity signaling) ...
A novel target for ADC tumor therapy LRRC15
A novel target for ADC tumor therapy LRRC15
2025-04-09
An abundant fibrotic stroma is a hallmark of most solid tumors, and stromal activation promotes tumorigenesis, therapeutic resistance, and metastatic dissemination of cancer cells....