Osteoclast differentiation and activation factor RANKL
Osteoclast differentiation and activation factor RANKL
2025-05-07
Receptor for activator of nuclear factor kappa-B (RANKL), also known as OPGL (CD254), is a member of the tumor necrosis factor ligand superfamily, member 11 (TNFSF11). It is a fact...
CD30 is a therapeutic target for lymphoma
CD30 is a therapeutic target for lymphoma
2025-05-06
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30 or Ki-1 antigen, is a receptor for TNFSF8/CD30L. It may play a role in the regulation of cell grow...
Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
2025-05-05
BackgroundIgG antibodies, essential for the normal functioning of the immune system, recognize antigens and neutralize pathogens through their Fab regions. Their Fc regions bind to...
The pleiotropic cytokine TGFB
The pleiotropic cytokine TGFB
2025-04-24
Transforming growth factor β (TGF - β, TGFB) is a multifunctional cytokine. TGF-β signaling is a key pathway in embryogenesis, tissue homeostasis, and cancer progression. TGF-β inc...
MSLN is the target of solid tumor treatment
MSLN is the target of solid tumor treatment
2025-04-22
Mesothelin (MSLN) is a cell-surface-bound glycosylphosphatidylinositol (GPI)-anchored protein. The membrane-anchored form may play a role in cell adhesion. Also known as megakaryoc...
Engineering IgG antibodies for intracellular targeting and drug delivery
Engineering IgG antibodies for intracellular targeting and drug delivery
2025-04-21
BackgroundMaking immunoglobulin G (IgG) antibodies autonomously internalize and localize to the cytoplasm of target cells (termed cytoplasmic-penetrating antibodies, CTs) is challe...
Bladder Cancer Treatment Target FGFR3
Bladder Cancer Treatment Target FGFR3
2025-04-16
Fibroblast growth factor receptor 3 (FGFR3) is a tyrosine protein kinase that acts as a cell surface receptor for fibroblast growth factor and is involved in regulating cell prolif...