The target of Insulin receptor INSR
The target of Insulin receptor INSR
2025-07-15
Insulin receptor (INSR), CD220 belongs to the receptor tyrosine kinase (RTK) family. It is a key membrane protein that mediates insulin signal transduction. It is mainly expressed ...
Tumor escape switch PD-1 PD-L1
Tumor escape switch PD-1 PD-L1
2025-07-14
PD-1 (programmed death receptor 1) and PD-L1 (programmed death ligand 1) are key immune checkpoint molecules that play a crucial role in regulating and balancing the immune system....
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design
2025-07-09
BackgroundAntibody (Ab) structures and antibody-antigen (Ag) interactions (AAI) are crucial for understanding immune recognition and designing Ab therapeutics. Although existing st...
The target of B-cell activating factor receptor BAFFR
The target of B-cell activating factor receptor BAFFR
2025-07-08
B-cell activating factor receptor (BAFFR), also known as TNFRSF13C and CD268, is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on the...
The target of MUC17 transmembrane mucin MUC17
The target of MUC17 transmembrane mucin MUC17
2025-07-07
Transmembrane mucins are major components of the gastric mucosal barrier, comprising a family of high-molecular-weight glycoproteins that are expressed by specialized epithelial ce...
Granulocyte colony stimulating factor receptor CSF3R
Granulocyte colony stimulating factor receptor CSF3R
2025-07-02
CSF3R is a granulocyte colony-stimulating factor receptor, also known as GCSF-R or CD114. It is essential for granulocyte maturation and plays a key role in the proliferation, diff...
The immunosuppressive enzyme CD39
The immunosuppressive enzyme CD39
2025-07-01
The ATP-adenosine pathway plays a key role in establishing an immunosuppressive tumor microenvironment (TME) by converting proinflammatory extracellular ATP into immunosuppressive ...