AbSet: A Standardized Data Set of Antibody Structures for Machine Learning Applications
AbSet: A Standardized Data Set of Antibody Structures for Machine Learning Applications
2025-05-26
BackgroundMachine learning algorithms have played a fundamental role in the development of therapeutic antibodies by training on sequence and/or structural datasets. However, struc...
Target of treatment for acute myeloid leukemia FLT3
Target of treatment for acute myeloid leukemia FLT3
2025-05-22
The receptor tyrosine kinase FLT3, also known as stem cell tyrosine kinase 1 (STK-1), fetal liver kinase-2 (FLK-2), and CD135, serves as the cell surface receptor for the cytokine ...
Myeloid inhibitory C-type lectin receptor CLEC12A
Myeloid inhibitory C-type lectin receptor CLEC12A
2025-05-21
C-type lectin domain family 12 member A (CLEC12A), also known as C-type lectin-like molecule-1 (CLL-1), myeloid inhibitory C-type lectin-like receptor (MICL) , killer cell lectin-l...
High-throughput strategies for monoclonal antibody screening: advances and challenges
High-throughput strategies for monoclonal antibody screening: advances and challenges
2025-05-20
BackgroundAntibodies with high affinity and specificity, obtained through high-throughput screening and rapid production, are crucial to the contemporary biomedical industry. Tradi...
Tumor immune escape promoting factor EpCAM
Tumor immune escape promoting factor EpCAM
2025-05-19
Epithelial cell adhesion molecule (EpCAM), also known as adenocarcinoma-associated antigen, epithelial glycoprotein (EGP), cell surface glycoprotein (TROP1), or M1S2, M4S1, MIC18, ...
CD37 as a Therapeutic Target for Acute Myeloid Leukemia
CD37 as a Therapeutic Target for Acute Myeloid Leukemia
2025-05-16
CD37 is a tetraspanin protein prominently expressed on the surface of B cells. It plays a crucial role in regulating B cell survival, shaping immune responses, and facilitating imm...
Alarm cytokine IL1A
Alarm cytokine IL1A
2025-05-15
Interleukin-1α (IL1A) is a major alarmin cytokine that triggers and enhances inflammatory responses. It plays a crucial role in inflammation and bridges the innate and adaptive imm...