T-cell activation inhibitor VISTA
T-cell activation inhibitor VISTA
2025-04-08
V-type immunoglobulin domain-containing inhibitor of T-cell activation (VISTA), also known as VISR, is a member of the B7 family. It is an immunomodulatory receptor that inhibits T...
Bispecific antibody heavy and light chain matching design
Bispecific antibody heavy and light chain matching design
2025-04-07
BackgroundThe correct assembly of a four-chain IgG-like bispecific composed of two different light and heavy chains requires the formation of three heterodimer interfaces: one form...
ADAM9 is a new target for ADC anticancer therapy
ADAM9 is a new target for ADC anticancer therapy
2025-04-03
A disintegrin and metalloproteinase 9 (ADAM9), also known as MDC9 or meltrin-γ, is a metalloproteinase that cleaves and releases numerous molecules important in tumorigenesis and a...
Allergic trigger IgE
Allergic trigger IgE
2025-04-02
T2 inflammation is propagated by several key cell types, including T helper 2 (Th2) cells, eosinophils, mast cells, and B cells. Immunoglobulin E (IgE), produced by B cells, is a k...
Antibody diversity and specificity and new insights into structure
Antibody diversity and specificity and new insights into structure
2025-04-01
BackgroundThe mysteries surrounding the mechanisms that generate antibody diversity were largely resolved in the 1970s with the discovery of variable gene rearrangement and somatic...
Angptl3 is a key regulator of lipid metabolism
Angptl3 is a key regulator of lipid metabolism
2025-03-31
Angiopoietin-related protein 3 (Angptl3) is a member of the angiopoietin-like protein (ANGPTL) family, also known as Ang-5 Angpt5 is involved in the regulation of lipid and gl...
HIV invades the coreceptor CCR5
HIV invades the coreceptor CCR5
2025-03-28
CC chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is associated with the immune system because it acts as a receptor ...