Tumor escape switch PD-1 PD-L1
Tumor escape switch PD-1 PD-L1
2025-07-14
PD-1 (programmed death receptor 1) and PD-L1 (programmed death ligand 1) are key immune checkpoint molecules that play a crucial role in regulating and balancing the immune system....
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design
2025-07-09
BackgroundAntibody (Ab) structures and antibody-antigen (Ag) interactions (AAI) are crucial for understanding immune recognition and designing Ab therapeutics. Although existing st...
The target of B-cell activating factor receptor BAFFR
The target of B-cell activating factor receptor BAFFR
2025-07-08
B-cell activating factor receptor (BAFFR), also known as TNFRSF13C and CD268, is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on the...
The target of MUC17 transmembrane mucin MUC17
The target of MUC17 transmembrane mucin MUC17
2025-07-07
Transmembrane mucins are major components of the gastric mucosal barrier, comprising a family of high-molecular-weight glycoproteins that are expressed by specialized epithelial ce...
Granulocyte colony stimulating factor receptor CSF3R
Granulocyte colony stimulating factor receptor CSF3R
2025-07-02
CSF3R is a granulocyte colony-stimulating factor receptor, also known as GCSF-R or CD114. It is essential for granulocyte maturation and plays a key role in the proliferation, diff...
The immunosuppressive enzyme CD39
The immunosuppressive enzyme CD39
2025-07-01
The ATP-adenosine pathway plays a key role in establishing an immunosuppressive tumor microenvironment (TME) by converting proinflammatory extracellular ATP into immunosuppressive ...
The therapeutic target of systemic lupus erythematosus BDCA2
The therapeutic target of systemic lupus erythematosus BDCA2
2025-06-30
CD303, also known as BDCA2, DLEC, or CLEC4C, is a unique type II C-type lectin receptor (CLR) found on human plasmacytoid dendritic cells (pDCs). It assists TLR-7/9 in recognizing ...