Engineered ipilimumab variants that bind human and mouse CTLA-4
Engineered ipilimumab variants that bind human and mouse CTLA-4
2025-02-18
BackgroundTesting candidate monoclonal antibody therapeutics in preclinical models is a critical step in drug development. Identifying antibody therapeutic candidates that bind to ...
The glucose regulatory receptor GIPR
The glucose regulatory receptor GIPR
2025-02-17
The gastric inhibitory peptide receptor (GIPR) is a receptor for glucose-dependent insulinotropic polypeptide (GIP) and belongs to the G protein-coupled receptor (GPCR) family. The...
T-cell immunomodulatory factor TIM3
T-cell immunomodulatory factor TIM3
2025-02-14
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3), also known as HAVCR2, is a member of the TIM family. It participates in regulating both innate and adaptive immu...
Therapeutic target of inflammatory bowel disease TL1A
Therapeutic target of inflammatory bowel disease TL1A
2025-02-10
TL1A is a member of the tumor necrosis factor ligand superfamily, member 15 (TNFSF15), also known as TL1 and VEGI. DcR3 is a functional ligand for TL1A, which plays an important ro...
APRIL is a therapeutic target for IgA nephropathy
APRIL is a therapeutic target for IgA nephropathy
2025-01-21
APRIL, a member of the tumor necrosis factor ligand superfamily, member 13 (TNFSF13, D256), is a proliferation-inducing ligand that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, playi...
Mechanisms treatment and management of tumors of the digestive system
Mechanisms treatment and management of tumors of the digestive system
2025-01-20
BackgroundDigestive system cancers are a leading cause of cancer-related morbidity and mortality worldwide, accounting for 35% of cancer deaths annually. These cancer entities are ...
Insulin-like growth factor 1 receptor IGF1R
Insulin-like growth factor 1 receptor IGF1R
2025-01-20
IGF1R, also known as the insulin-like growth factor 1 receptor (CD221), is a type II tyrosine kinase receptor that regulates cell growth and proliferation and is activated by IGF1,...