Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
Recombinant antibodies: antibody sequencing and artificial intelligence help antibody design
2024-10-14
Antibodies can be synthesized through a variety of strategies, starting with polyclonal antibodies produced through animal immunization, followed by monoclonal antibodies produced ...
Hepatocyte growth factor receptor c-MET
Hepatocyte growth factor receptor c-MET
2024-10-11
c-MET, also known as MET or hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase belonging to the MET family. Hepatocyte growth factor (HGF) is a specific ligand...
The role of glycosylation in cancer and clinical therapy
The role of glycosylation in cancer and clinical therapy
2024-10-09
BackgroundGlycosylation is a key protein modification in vivo, playing an important role in regulating various biological functions by influencing protein folding, transport, and l...
The target of angiogenesis regulation is DLL4
The target of angiogenesis regulation is DLL4
2024-10-08
DLL4, short for delta-like protein 4, is a Notch ligand that participates in the Notch signaling pathway, activating NOTCH1 and NOTCH4. It is involved in angiogenesis and negativel...
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
2024-10-08
BackgroundCancer immunotherapy, represented by immune checkpoint inhibitors (ICIs), has reshaped the treatment paradigm for advanced non-small cell lung cancer and small cell lung ...
Autoimmune cancer testicular antigen NY-ESO-1
Autoimmune cancer testicular antigen NY-ESO-1
2024-09-26
NY-ESO-1, also known as CTA1B (CTAG1B), is an autoimmune cancer antigen presented on the cell surface by major histocompatibility complex class I molecules and exhibits restri...
The hepatocellular carcinoma marker GPC3
The hepatocellular carcinoma marker GPC3
2024-09-24
Glypican-3 (GPC3) is a member of the heparan sulfate (HS) proteoglycan family. Anchored to the cell membrane via phosphatidylinositol, it serves as a multifunctional co-receptor on...