Development of bispecific antibody-drug conjugates targeting EpCAM and CLDN3
Development of bispecific antibody-drug conjugates targeting EpCAM and CLDN3
2025-03-27
BackgroundEpithelial cell adhesion molecule (EpCAM), a tumor antigen targeted by antibody-drug conjugates (ADCs), is highly expressed in many epithelial cancers. However, clinical ...
The chemokine receptor CCR4
The chemokine receptor CCR4
2025-03-27
CCR4, also known as CD194 or CMKBR4, is a chemokine receptor. It is a G protein-coupled receptor (GPCR) used for signal transduction, causing cell chemotaxis and activation. CCR4 i...
CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells
CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells
2025-03-25
BackgroundTumor-infiltrating regulatory T cells (TI-Tregs) are key components of the tumor microenvironment (TME) that promote immune evasion and drive tumor progression. Although ...
The folate receptor FOLR1
The folate receptor FOLR1
2025-03-24
Folate receptor α (FOLR1 / FRα) is a high-affinity folate-binding protein and one of the major folate transporters. Overexpression of FOLR1 is often associated with accelerated can...
Don't eat my signaling protein CD47
Don't eat my signaling protein CD47
2025-03-21
The leukocyte surface antigen CD47, also known as MER6 or IAP, is a ligand for signal regulatory protein α (SIRPα). Its extracellular domain (ECD) is a cell surface self-marker tha...
Macrophage migration inhibitor MIF
Macrophage migration inhibitor MIF
2025-03-20
Macrophage migration inhibitory factor (MIF) has been discovered as an inhibitor of T lymphocyte induction and acts as a pleiotropic proinflammatory cytokine. It is involved in var...
Advancements in Escherichia coli secretion systems for enhanced recombinant protein production
Advancements in Escherichia coli secretion systems for enhanced recombinant protein production
2025-03-18
BackgroundEscherichia coli is one of the most studied microorganisms in microbiology. Due to its rapid growth, ease of genetic manipulation, and relatively high protein yields, it ...