The immunosuppressive molecule B7H4
The immunosuppressive molecule B7H4
2024-12-23
B7H4, V-set domain-containing inhibitor of T-cell activation 1 (VTCN1), also known as B7x, is a member of the B7 family and an inhibitory immune checkpoint. It negatively regulates...
Potent AMA1-specific human monoclonal antibody against Plasmodium vivax
Potent AMA1-specific human monoclonal antibody against Plasmodium vivax
2024-12-20
BackgroundPlasmodium vivax malaria is easily transmitted and remains dormant in the liver, with repeated relapses contributing to the clinical burden. Therefore, new treatments are...
claudin18.2 is a new target for gastric and pancreatic cancer
claudin18.2 is a new target for gastric and pancreatic cancer
2024-12-19
BackgroundRecent advances in the study of CLDN18.2 (Claudin18.2) in gastric and pancreatic cancers have made CLDN18.2 a promising therapeutic target for these two cancers. CLDN18.2...
Angiogenesis regulatory target ANGPT2
Angiogenesis regulatory target ANGPT2
2024-12-17
ANGPT2, also known as ANG-2, is an angiopoietin that binds to TEK/TIE2, competing for ANGPT1 binding sites and modulating ANGPT1 signaling. Ang2 binds to the TIE2 receptor with the...
Autoimmune disease treatment target IL23A
Autoimmune disease treatment target IL23A
2024-12-16
IL23A is the α subunit of interleukin-23 , also known as IL-23p19. It combines with IL12B to form the proinflammatory cytokine IL-23, which plays distinct roles in innate and adapt...
B and T lymphocyte attenuator BTLA
B and T lymphocyte attenuator BTLA
2024-12-13
BTLA, also known as CD272, is a B and T lymphocyte attenuator. The BTLA protein belongs to the CD28 immunoglobulin superfamily (IgSF). BTLA recognizes the ligand HVEM/CD270 and is ...
Immune stimulation of the cytokine IL-15
Immune stimulation of the cytokine IL-15
2024-12-12
IL-15 is a potent immunostimulatory cytokine that enhances T and NK cell immune responses. IL-15 promotes tissue protection by promoting the clearance of infected cells. IL-15 dysr...