T cell-specific surface glycoprotein CD28
T cell-specific surface glycoprotein CD28
2025-01-17
T cell-specific surface glycoprotein CD28, is a founding member of the immunoglobulin (Ig) costimulatory receptor family. It plays a crucial role in T-cell activation, proliferatio...
The immune checkpoint LAG-3
The immune checkpoint LAG-3
2025-01-16
Lymphocyte activation gene 3 (LAG-3), also known as CD223, is an inhibitory receptor highly expressed by exhausted T cells. In the tumor microenvironment, elevated expression of im...
CD123 is a therapeutic target for blood diseases
CD123 is a therapeutic target for blood diseases
2025-01-14
CD123 is the alpha chain of the interleukin-3 receptor (IL-3RA). IL-3Rs are members of the beta common (C) receptor family, which includes the IL-5R and granulocyte-...
Role of CCR2-CCL2 axis in cancer immunity
Role of CCR2-CCL2 axis in cancer immunity
2025-01-13
CCR2 is a CC2-type chemokine receptor, also known as monocyte-attracting protein-1 receptor (MCP-1-R) or CD192. CCR2 is a key functional receptor for CCL2. The CCR2/CCR2 axis direc...
Nectin-4 is a novel target of the ADC circuit
Nectin-4 is a novel target of the ADC circuit
2025-01-10
Nectin-4, also known as poliovirus receptor-associated protein 4, is closely associated with tumor growth, angiogenesis, metastasis, and recurrence. Due to its target-specific expr...
The cadherin CDH6
The cadherin CDH6
2025-01-09
CDH6, also known as fetal kidney cadherin or K-cadherin, is involved in the morphogenesis and development of the embryonic kidney, driving the mesenchymal-epithelial differentiatio...
Key differences and limitations of antibody numbering schemes
Key differences and limitations of antibody numbering schemes
2025-01-07
Background      The complementarity-determining regions (CDRs) of antibodies are the most diverse regions in terms of sequence and structural characteristics an...