The pleiotropic cytokine IL9
2025-03-07
Interleukin 19 (IL19), a member of the IL-2RγC chain family, is a pleiotropic cytokine that regulates the functions of various cells. Originally identified as a growth factor for T...
Dual inhibition of a novel bispecific antibody CDX-622
2025-03-05
BackgroundBiologically based therapies targeting cytokine pathways have demonstrated significant clinical benefit in a number of inflammatory and autoimmune diseases. Many of these...
The target of tumor immunotherapy is MUC1
2025-03-03
Mucin1 (MUC1, also known as EMA, MCD, PEM, PUM, KL-6, and MAM6) is a large protein. It is the most recognizable transmembrane protein in the mucin family and has a heavily glycosyl...
De novo designed proteins neutralize lethal snake venom toxins
2025-02-25
BackgroundSnakebite envenomation is a devastating and neglected tropical disease that causes severe complications and disability in humans. Three-finger toxin (3FTx), the highly to...
Receptor-ligand interactions for optimized endocytosis in targeted therapies
2025-02-24
BackgroundReceptor-mediated endocytosis plays a crucial role in the success of numerous therapeutics and remains central to advancing drug development. The process begins with liga...
B-lymphocyte antigen CD20
2025-02-21
B-lymphocyte antigen (CD20), also known as MS4A1, plays a role in regulating cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. CD20 ...
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
2025-02-20
BackgroundThe mucin O-glycan sialylTn antigen (sTn, Neu5Acα2-6GalNAcα1-O-Ser/Thr) is an antigen associated with diverse cancer types and is generally associated with a higher risk ...