Mechanisms treatment and management of tumors of the digestive system
Mechanisms treatment and management of tumors of the digestive system
2025-01-20
BackgroundDigestive system cancers are a leading cause of cancer-related morbidity and mortality worldwide, accounting for 35% of cancer deaths annually. These cancer entities are ...
Insulin-like growth factor 1 receptor IGF1R
Insulin-like growth factor 1 receptor IGF1R
2025-01-20
IGF1R, also known as the insulin-like growth factor 1 receptor (CD221), is a type II tyrosine kinase receptor that regulates cell growth and proliferation and is activated by IGF1,...
T cell-specific surface glycoprotein CD28
T cell-specific surface glycoprotein CD28
2025-01-17
T cell-specific surface glycoprotein CD28, is a founding member of the immunoglobulin (Ig) costimulatory receptor family. It plays a crucial role in T-cell activation, proliferatio...
The immune checkpoint LAG-3
The immune checkpoint LAG-3
2025-01-16
Lymphocyte activation gene 3 (LAG-3), also known as CD223, is an inhibitory receptor highly expressed by exhausted T cells. In the tumor microenvironment, elevated expression of im...
CD123 is a therapeutic target for blood diseases
CD123 is a therapeutic target for blood diseases
2025-01-14
CD123 is the alpha chain of the interleukin-3 receptor (IL-3RA). IL-3Rs are members of the beta common (C) receptor family, which includes the IL-5R and granulocyte-...
Role of CCR2-CCL2 axis in cancer immunity
Role of CCR2-CCL2 axis in cancer immunity
2025-01-13
CCR2 is a CC2-type chemokine receptor, also known as monocyte-attracting protein-1 receptor (MCP-1-R) or CD192. CCR2 is a key functional receptor for CCL2. The CCR2/CCR2 axis direc...
Nectin-4 is a novel target of the ADC circuit
Nectin-4 is a novel target of the ADC circuit
2025-01-10
Nectin-4, also known as poliovirus receptor-associated protein 4, is closely associated with tumor growth, angiogenesis, metastasis, and recurrence. Due to its target-specific expr...