Autoimmune disease treatment target IL23A
2024-12-16
IL23A is the α subunit of interleukin-23 , also known as IL-23p19. It combines with IL12B to form the proinflammatory cytokine IL-23, which plays distinct roles in innate and adapt...
B and T lymphocyte attenuator BTLA
2024-12-13
BTLA, also known as CD272, is a B and T lymphocyte attenuator. The BTLA protein belongs to the CD28 immunoglobulin superfamily (IgSF). BTLA recognizes the ligand HVEM/CD270 and is ...
Immune stimulation of the cytokine IL-15
2024-12-12
IL-15 is a potent immunostimulatory cytokine that enhances T and NK cell immune responses. IL-15 promotes tissue protection by promoting the clearance of infected cells. IL-15 dysr...
Immunoregulatory factor IL-22
2024-12-12
Interleukin-22 (IL22) is a cytokine that regulates tissue responses during inflammation and is a member of the IL10 cytokine family. It belongs to the class II cytokine and shares ...
Strategies to boost antibody selectivity in oncology
2024-12-10
BackgroundAntibodies in oncology have toxic substances and effector functions that can kill cells at very low concentrations. A key challenge is that most targets on cancer cells a...
Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture
2024-12-09
BackgroundChinese hamster ovary (CHO) cells are the most widely used mammalian host cell for commercial production of therapeutic antibodies. Fed-batch cultures are widely used for...
GDF15 is a therapeutic target for obesity
2024-12-05
Growth differentiation factor 1 5 (GDF15), also known as macrophage inhibitory cytokine 1 (MIC1), is a diverse member of the transforming growth factor (TGF-β) superfamily. It is a...