Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
Mapping affinity and allostery in human IgG antibody Fc region-Fcγ receptor interactions
2025-05-05
BackgroundIgG antibodies, essential for the normal functioning of the immune system, recognize antigens and neutralize pathogens through their Fab regions. Their Fc regions bind to ...
The pleiotropic cytokine TGFB
The pleiotropic cytokine TGFB
2025-04-24
Transforming growth factor β (TGF - β, TGFB) is a multifunctional cytokine. TGF-β signaling is a key pathway in embryogenesis, tissue homeostasis, and cancer progression. TGF-β incl...
MSLN is the target of solid tumor treatment
MSLN is the target of solid tumor treatment
2025-04-22
Mesothelin (MSLN) is a cell-surface-bound glycosylphosphatidylinositol (GPI)-anchored protein. The membrane-anchored form may play a role in cell adhesion. Also known as megakaryocy...
Engineering IgG antibodies for intracellular targeting and drug delivery
Engineering IgG antibodies for intracellular targeting and drug delivery
2025-04-21
BackgroundMaking immunoglobulin G (IgG) antibodies autonomously internalize and localize to the cytoplasm of target cells (termed cytoplasmic-penetrating antibodies, CTs) is challen...
Bladder Cancer Treatment Target FGFR3
Bladder Cancer Treatment Target FGFR3
2025-04-16
Fibroblast growth factor receptor 3 (FGFR3) is a tyrosine protein kinase that acts as a cell surface receptor for fibroblast growth factor and is involved in regulating cell prolife...
The cannabinoid receptor CNR1
The cannabinoid receptor CNR1
2025-04-15
Cannabinoid receptor 1 (CNR1), also known as CB1 or CBR, is a G protein-coupled receptor (GPCR) for endocannabinoids (eCBs) and has therapeutic potential in diseases such as pain, a...
Inactivated tyrosine protein kinase PTK7
Inactivated tyrosine protein kinase PTK7
2025-04-14
Inactive protein tyrosine kinase 7 (PTK7), also known as colon cancer kinase 4 (CCK-4), is a component of both the non-canonical (also known as Wnt/planar cell polarity signaling) a...