The Effects of Codon Usage on Protein Structure and Folding
The Effects of Codon Usage on Protein Structure and Folding
2024-09-18
BackgroundThe increasing sophistication of machine learning algorithms has enabled the prediction of protein structure based solely on amino acid sequence, and these methods have h...
Developability considerations for bispecific and multispecific antibodies
Developability considerations for bispecific and multispecific antibodies
2024-09-12
BackgroundBispecific antibodies (bsAbs) and multispecific antibodies (msAbs) encompass a wide range of formats and can simultaneously bind multiple epitopes, unlocking mechanisms t...
The cell adhesion molecule ICAM1
The cell adhesion molecule ICAM1
2024-09-11
ICAM-1, also known as CD54, is a cell surface glycoprotein. It acts as a biosensor, transducing outside-in signals through its cytoplasmic domain, which binds to the extracellular ...
The inhibitory receptor TIGIT
The inhibitory receptor TIGIT
2024-09-10
TIGIT is a T cell immunoreceptor with both Ig and ITIM domains. It is an inhibitory receptor, also known as VSIG9 and VSTM3. It binds with high affinity to the poliovirus receptor ...
Suitable conditions were selected for eukaryotic protein expression
Suitable conditions were selected for eukaryotic protein expression
2024-09-09
Eukaryotic mammalian expression systems play a crucial role in protein expression technology. Mammalian protein production has become the standard for the production of state-of-th...
Immune stimulation of the cytokine IL-21
Immune stimulation of the cytokine IL-21
2024-09-05
Interleukin-21 (IL-21) is an immunostimulatory cytokine that belongs to the common gamma-chain cytokine family. It plays an important role in the development, differentiation, prol...
Novel immunotherapeutics against LGR5 to target multiple cancer types
Novel immunotherapeutics against LGR5 to target multiple cancer types
2024-09-04
BackgroundLeucine-rich repeat-containing G protein receptor 5 (LGR5) is a target gene of the oncogenic Wnt signaling pathway in colorectal cancer cells. LGR5 is overexpressed in hu...