The challenges and breakthroughs in the development of diagnostic monoclonal antibodies
The challenges and breakthroughs in the development of diagnostic monoclonal antibodies
2024-07-18
BackgroundIn vitro diagnostics (IVD) are a vital component of the biopharmaceutical industry, boasting a highly cost-effective industry. Retaining only 3% of medical resources, the...
Engineering a tumor selective prodrug T-cell engager bispecific antibody for safer immunotherapy
Engineering a tumor selective prodrug T-cell engager bispecific antibody for safer immunotherapy
2024-07-16
BackgroundOver the past decade, cancer immunotherapies that harness the adaptive immune response to destroy tumors have made substantial progress, particularly in extending surviva...
The introduction of protein tag
The introduction of protein tag
2024-07-12
Recombinant proteins are proteins obtained through the use of recombinant gene cloning techniques. Recombinant protein expression technology has been widely used in various fields ...
Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance based relative binding activity assessment
Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance based relative binding activity assessment
2024-07-11
BackgroundMonoclonal antibodies are widely used to treat a variety of diseases, including cancer, autoimmune diseases, and metabolic disorders. As of June 24, 2024, nearly 214 ther...
The binding mechanism of an anti multiple myeloma antibody to the human GPRC5D homodimer
The binding mechanism of an anti multiple myeloma antibody to the human GPRC5D homodimer
2024-07-05
BackgroundMultiple myeloma (MM) is the second most common hematological malignancy, characterized by the uncontrolled proliferation and accumulation of monoclonal plasma cells in t...
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
2024-07-04
BackgroundChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world, accounting for 4,000 deaths annually in the United States. It is characterized ...
Central nervous system specific proteins S100β
Central nervous system specific proteins S100β
2024-07-03
S100β is a central nervous system-specific protein, also known as the brain's "C-reactive protein" or S100B. Primarily distributed in the central nervous system, it is synthesized ...