Strategies to boost antibody selectivity in oncology
2024-12-10
BackgroundAntibodies in oncology have toxic substances and effector functions that can kill cells at very low concentrations. A key challenge is that most targets on cancer cells a...
Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture
2024-12-09
BackgroundChinese hamster ovary (CHO) cells are the most widely used mammalian host cell for commercial production of therapeutic antibodies. Fed-batch cultures are widely used for...
GDF15 is a therapeutic target for obesity
2024-12-05
Growth differentiation factor 1 5 (GDF15), also known as macrophage inhibitory cytokine 1 (MIC1), is a diverse member of the transforming growth factor (TGF-β) superfamily. It is a...
Engineered antibody fusion proteins for targeted disease therapy
2024-12-02
BackgroundSince the first therapeutic antibody was approved by the FAD, antibody products have developed rapidly in the drug market. Building on the success of monoclonal antibodie...
Immunomodulatory adenosine producer CD73
2024-11-29
CD73 is a 5'-nucleotidase exonuclease (NT5E). The CD73-mediated adenosine pathway converts inflammatory ATP into the immunosuppressant adenosine, which inhibits immune activation t...
Prostate specific membrane antigen PSMA
2024-11-26
Prostate-specific membrane antigen (PMSA), also known as glutamate carboxypeptidase II (GCPII) and folate hydrolase (FolH1), is a zinc-dependent metalloproteinase. PSMA is primaril...
SSTR2 is a therapeutic target for neuroendocrine tumors
2024-11-25
The somatostatin receptor (SSTR2) is a member of the G protein-coupled receptor (GPCR) superfamily, expressed in the central nervous system, particularly the hypothalamus, as well ...