Fc enhanced anti CTLA-4 antibody Botensilimab treats tumors that respond poorly to conventional immunotherapy
Fc enhanced anti CTLA-4 antibody Botensilimab treats tumors that respond poorly to conventional immunotherapy
2024-08-23
BackgroundImmune checkpoint inhibitors (ICIs) that block cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death receptor 1 (PD-1), and programmed death receptor ligand 1 ...
B-cell maturation antigen BCMA
B-cell maturation antigen BCMA
2024-08-20
BCMA, a member of the tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B-cell maturation antigen (CD269), promotes B-cell survival and plays a role i...
Inducible T-cell costimulator ICOS
Inducible T-cell costimulator ICOS
2024-08-19
Inducible T-cell co-stimulator (ICOS, CD278) is an activating co-stimulatory immune checkpoint expressed on activated T cells. It can induce T-cell proliferation, survival, and dif...
Immune checkpoint suppressor molecule Siglec15
Immune checkpoint suppressor molecule Siglec15
2024-08-16
Siglec-15, also known as sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15), also known as CD33 antigen-like 3, belongs to the Siglec family. Siglec-15 is a key immunosu...
Accurate prediction of protein function using statistics informed graph networks
Accurate prediction of protein function using statistics informed graph networks
2024-08-14
BackgroundUnderstanding protein function is crucial for understanding the complex mechanisms of many key biological activities and has profound implications for medicine, biotechno...
Single domain antibodies as therapeutics for solid tumor treatment
Single domain antibodies as therapeutics for solid tumor treatment
2024-08-13
BackgroundTraditional cancer treatments, including surgery, chemotherapy, and radiotherapy, are often poorly targeted and, while killing tumor cells, can damage normal cells, resul...
Lipid control protein PCSK9
Lipid control protein PCSK9
2024-08-12
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted serine protease primarily synthesized in the liver. It primarily binds to the low-density lipoprotein receptor (...