The introduction of ADC drug Payload
The introduction of ADC drug Payload
2024-06-04
Antibody-drug conjugates (ADCs) are a promising cancer treatment, capable of selectively delivering a cytotoxic payload to tumors while minimizing the severity of side effects . AD...
Two sided interferon IFNγ
Two sided interferon IFNγ
2024-06-03
IFNγ is a cytokine and the only member of the type II interferon family. It plays a crucial role in tissue homeostasis, immune and inflammatory responses, and tumor immunosurveilla...
Cancer therapy with antibodies
Cancer therapy with antibodies
2024-05-24
BackgroundThe greatest challenge in cancer treatment is eradicating cancer cells with minimal loss of normal cells. To address this challenge, targeted therapies have been develope...
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
2024-05-23
BackgroundBispecific antibodies are artificial molecules that fuse the two distinct antigen-binding sites of a monoclonal antibody into a single entity. They have emerged as a prom...
The stem cell factor receptor CD117
The stem cell factor receptor CD117
2024-05-22
CD117, also known as c-Kit, KIT or stem cell factor (SCF) receptor, is a type III tyrosine protein kinase that plays an important role in cell survival and proliferation, hematopoi...
Interleukin-7 receptor alpha subunit CD127
Interleukin-7 receptor alpha subunit CD127
2024-05-21
CD127 is the alpha subunit of the interleukin-7 receptor (IL-7Rα). It also functions as a receptor for thymic stromal lymphopoietin (TSLP). CD127 regulates the proliferation, diffe...
Next generation anti-PD-L1 IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
Next generation anti-PD-L1 IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
2024-05-17
BackgroundAntibody-cytokine fusion proteins (also known as immunocytokines) deliver these immunostimulatory payloads to tumor lesions, significantly broadening the therapeutic wind...