The heart failure marker ST2
2024-06-14
ST2, short for growth stimulation expressed gene 2 (ST2), also known as Suppression of Tumorigenicity 2, is a member of the interleukin-1 receptor family and was formerly known as ...
Development and characterization of a pharmacokinetics (PK) assay for T-cell involved bispecific antibody cibisatamab
2024-06-13
BackgroundAppropriately designed pharmacokinetic (PK) assays that are sensitive to the effects of antidrug antibodies (ADAs) on relevant exposures are an alternative strategy for u...
Structural basis for selectivity and antagonism in extracellular GPCR nanobodies
2024-06-12
BackgroundG protein-coupled receptors (GPCRs) are important therapeutic targets, but their complex structures pose challenges for effective drug design. Nanobodies (i.e., single-do...
Heart failure biomarkers NT-ProBNP and BNP
2024-06-11
B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) both belong to the natriuretic peptide (NP) family. Concentrations of NT-proBNP and BNP i...
Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution
2024-06-07
BackgroundThe dendritic cell inhibitory receptor (DCIR) is a C-type lectin receptor selectively expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and n...
AggreProt: a web server for predicting and engineering aggregation pron eregions in proteins
2024-06-06
BackgroundRecombinant proteins play a key role in many applications, including industrial biocatalysis and therapeutics. Despite recent advances in computational protein structure ...
The key factors in IgG1 secretion are CH-CL pairing and VL domain integrity
2024-06-05
BackgroundThe CH1 domain of IgG antibodies controls antibody assembly and secretion through the endoplasmic reticulum protein quality control (ERQC) mechanism, mediated by the mole...