Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
2024-10-08
BackgroundCancer immunotherapy, represented by immune checkpoint inhibitors (ICIs), has reshaped the treatment paradigm for advanced non-small cell lung cancer and small cell lung ...
Autoimmune cancer testicular antigen NY-ESO-1
Autoimmune cancer testicular antigen NY-ESO-1
2024-09-26
NY-ESO-1, also known as CTA1B (CTAG1B), is an autoimmune cancer antigen presented on the cell surface by major histocompatibility complex class I molecules and exhibits restri...
The hepatocellular carcinoma marker GPC3
The hepatocellular carcinoma marker GPC3
2024-09-24
Glypican-3 (GPC3) is a member of the heparan sulfate (HS) proteoglycan family. Anchored to the cell membrane via phosphatidylinositol, it serves as a multifunctional co-receptor on...
The proinflammatory cytokine IL18
The proinflammatory cytokine IL18
2024-09-20
Interleukin 18 (IL18), a member of the IL-1 cytokine family, is a proinflammatory cytokine that induces IFNγ production and plays a crucial role in inflammation. It is primarily in...
The unique cadherin CDH17
The unique cadherin CDH17
2024-09-20
CDH17 is a cadherin protein belonging to a subclass of the 7D-cadherin family. Its primary function is cell-cell adhesion, which may be involved in tumorigenesis. The adhesion mech...
Improving Protein Expression, Stability, and Function with ProteinMPNN
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024-09-18
BackgroundNatural proteins are highly optimized for function but are often difficult to produce at scales suitable for biotechnological applications due to poor expression in heter...
The Effects of Codon Usage on Protein Structure and Folding
The Effects of Codon Usage on Protein Structure and Folding
2024-09-18
BackgroundThe increasing sophistication of machine learning algorithms has enabled the prediction of protein structure based solely on amino acid sequence, and these methods have h...