Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance based relative binding activity assessment
Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance based relative binding activity assessment
2024-07-11
BackgroundMonoclonal antibodies are widely used to treat a variety of diseases, including cancer, autoimmune diseases, and metabolic disorders. As of June 24, 2024, nearly 214 ther...
The binding mechanism of an anti multiple myeloma antibody to the human GPRC5D homodimer
The binding mechanism of an anti multiple myeloma antibody to the human GPRC5D homodimer
2024-07-05
BackgroundMultiple myeloma (MM) is the second most common hematological malignancy, characterized by the uncontrolled proliferation and accumulation of monoclonal plasma cells in t...
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
2024-07-04
BackgroundChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world, accounting for 4,000 deaths annually in the United States. It is characterized ...
Central nervous system specific proteins S100β
Central nervous system specific proteins S100β
2024-07-03
S100β is a central nervous system-specific protein, also known as the brain's "C-reactive protein" or S100B. Primarily distributed in the central nervous system, it is synthesized ...
A new marker for ovarian cancer detection HE4
A new marker for ovarian cancer detection HE4
2024-07-02
Human epididymis protein 4 ( HE4), also known as WFDC2 , is a member of the whey acidic protein (WAP) family. HE4 is expressed at low levels in normal tissues but is highly express...
Ovarian cancer marker CA125
Ovarian cancer marker CA125
2024-06-27
The carbohydrate antigen CA125, also known as mucin 16 (MUC16), is a glycoprotein encoded by the MUC16 gene. It is expressed in epithelial ovarian tumors and various other patholog...
Hepatocellular carcinoma biomarker AFP
Hepatocellular carcinoma biomarker AFP
2024-06-25
Alpha-fetoprotein (AFP) is a glycoprotein synthesized primarily by the yolk sac and fetal liver during embryogenesis. Its primary function is to promote cell growth and development...