Cancer therapy with antibodies
Cancer therapy with antibodies
2024-05-24
BackgroundThe greatest challenge in cancer treatment is eradicating cancer cells with minimal loss of normal cells. To address this challenge, targeted therapies have been develope...
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
Macrophage-engaging peptidic bispecific antibodies（pBsAbs）for immunotherapy via a facile bioconjugation strategy
2024-05-23
BackgroundBispecific antibodies are artificial molecules that fuse the two distinct antigen-binding sites of a monoclonal antibody into a single entity. They have emerged as a prom...
The stem cell factor receptor CD117
The stem cell factor receptor CD117
2024-05-22
CD117, also known as c-Kit, KIT or stem cell factor (SCF) receptor, is a type III tyrosine protein kinase that plays an important role in cell survival and proliferation, hematopoi...
Interleukin-7 receptor alpha subunit CD127
Interleukin-7 receptor alpha subunit CD127
2024-05-21
CD127 is the alpha subunit of the interleukin-7 receptor (IL-7Rα). It also functions as a receptor for thymic stromal lymphopoietin (TSLP). CD127 regulates the proliferation, diffe...
Next generation anti-PD-L1 IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
Next generation anti-PD-L1 IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
2024-05-17
BackgroundAntibody-cytokine fusion proteins (also known as immunocytokines) deliver these immunostimulatory payloads to tumor lesions, significantly broadening the therapeutic wind...
CD74 supports accumulation and function of regulatory T-cells in tumors
CD74 supports accumulation and function of regulatory T-cells in tumors
2024-05-16
BackgroundRegulatory T cells (Tregs) are a heterogeneous population essential for maintaining homeostasis and controlling immune responses. Tregs can also suppress tumor immunity. ...
CD74 is a cell surface receptor for the macrophage factor MIF
CD74 is a cell surface receptor for the macrophage factor MIF
2024-05-15
CD74 is the MHC class II histocompatibility antigen gamma chain, also known as the HLA-DR antigen-associated invariant chain. It plays a key role in MHC class II antigen processing...