The IL-7 fusion protein F8 (scDb) IL7 up regulates TCF1 and promotes PD-1 blockade
The IL-7 fusion protein F8 (scDb) IL7 up regulates TCF1 and promotes PD-1 blockade
2024-08-27
BackgroundAnti-PD-1 antibodies have transformed cancer immunotherapy by inducing long-term complete remissions in a subset of patients. However, studies have shown that a significa...
A two-component T-cell activation therapy MATCH
A two-component T-cell activation therapy MATCH
2024-08-26
BackgroundMultispecific T cell adhesion scaffolds have become effective anticancer therapies for hematologic malignancies. Strategies are needed to modulate cancer cell targeting a...
Fc enhanced anti CTLA-4 antibody Botensilimab treats tumors that respond poorly to conventional immunotherapy
Fc enhanced anti CTLA-4 antibody Botensilimab treats tumors that respond poorly to conventional immunotherapy
2024-08-23
BackgroundImmune checkpoint inhibitors (ICIs) that block cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death receptor 1 (PD-1), and programmed death receptor ligand 1 ...
B-cell maturation antigen BCMA
B-cell maturation antigen BCMA
2024-08-20
BCMA, a member of the tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B-cell maturation antigen (CD269), promotes B-cell survival and plays a role i...
Inducible T-cell costimulator ICOS
Inducible T-cell costimulator ICOS
2024-08-19
Inducible T-cell co-stimulator (ICOS, CD278) is an activating co-stimulatory immune checkpoint expressed on activated T cells. It can induce T-cell proliferation, survival, and dif...
Immune checkpoint suppressor molecule Siglec15
Immune checkpoint suppressor molecule Siglec15
2024-08-16
Siglec-15, also known as sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15), also known as CD33 antigen-like 3, belongs to the Siglec family. Siglec-15 is a key immunosu...
Accurate prediction of protein function using statistics informed graph networks
Accurate prediction of protein function using statistics informed graph networks
2024-08-14
BackgroundUnderstanding protein function is crucial for understanding the complex mechanisms of many key biological activities and has profound implications for medicine, biotechno...