Targeted MMP9 therapy synergistically improves anti-PD1 efficacy
Targeted MMP9 therapy synergistically improves anti-PD1 efficacy
2023-12-20
The gain of function (GOF) CTNNB1 mutations (CTNNB1GOF) have been shown to be associated with immune rejection in hepatocellular carcinoma (HCC), leading to primary resis...
Comparison of mapping techniques of different antibody epitopes
Comparison of mapping techniques of different antibody epitopes
2023-12-11
During antibody development, selecting the right antibody that binds to the correct epitope of an antigen is crucial for achieving optimal therapeutic efficacy and leveraging the d...
Cytotoxic T-cell surface key molecule CD4
Cytotoxic T-cell surface key molecule CD4
2023-12-11
Like CD8, CD4 is a transmembrane glycoprotein that acts as a coreceptor for the T cell receptor (TCR) . Like the TCR, CD4 binds to major histocompatibility complex (MHC) molecules ...
Cytotoxic T-cell surface key molecule CD8
Cytotoxic T-cell surface key molecule CD8
2023-12-02
CD8 is a transmembrane glycoprotein that acts as a coreceptor for the T cell receptor (TCR). Like the TCR, CD8 binds to major histocompatibility complex (MHC) molecules but has spe...
SND1: potential prostate cancer target
SND1: potential prostate cancer target
2023-12-01
The most common genetic alteration in human prostate cancer (PC) is a gene fusion involving the androgen-regulated TMPRSS2 gene and the coding sequence of a member of the ETS famil...
T-lymphocyte surface key molecule CD3
T-lymphocyte surface key molecule CD3
2023-11-15
CD3 protein is one of the key molecules in the immune system, involved in activating cytotoxic T cells (CD8+ naive T cells) and T helper cells (CD4+ naive T cells), responsible for...
Polygenic proinflammatory cytokine IL6
Polygenic proinflammatory cytokine IL6
2023-11-09
Interleukin-6 is a multifactorial proinflammatory cytokine, a hemoglobin complex composed of IL-6, its receptor IL6R, and glycoprotein 130 (IL-6/ILL-6R/GP130). This complex complex...