Fc engineering modification for regulating antibody function
Fc engineering modification for regulating antibody function
2024-01-23
For general detection antibodies, we mainly consider their specificity and affinity, but for functional therapeutic antibodies, in addition to these two indicators, we also need to...
The lipid antigen presenting molecule CD1a
The lipid antigen presenting molecule CD1a
2024-01-17
CD1a is a transmembrane protein that belongs to the CD1 family and plays an important role in the immune system. The CD1 family includes CD1a, CD1b, CD1c, and CD1d, which are close...
Inflammatory cytokine IL1β
Inflammatory cytokine IL1β
2024-01-17
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven agonistic ligands (IL-1a and IL-1β, IL-18, IL-33, IL-36A, and IL-36T)...
Characterization of neutralizing antibodies of broad spectrum glutenopeptide HLA-DQ2.5 complex
Characterization of neutralizing antibodies of broad spectrum glutenopeptide HLA-DQ2.5 complex
2024-01-04
Celiac disease (CeD), also known as gluten-sensitive enteropathy, is an autoimmune disease of the small intestine associated with the ingestion of gluten. Gluten is present in food...
Key molecules on the surface of cytotoxic T-cells TNFa
Key molecules on the surface of cytotoxic T-cells TNFa
2023-12-27
Tumor necrosis factor TNFa Necrosis Factor-alpha is a cytokine that was originally discovered to be associated with anti-tumor activity and has been identified as a major...
Targeted MMP9 therapy synergistically improves anti-PD1 efficacy
Targeted MMP9 therapy synergistically improves anti-PD1 efficacy
2023-12-20
The gain of function (GOF) CTNNB1 mutations (CTNNB1GOF) have been shown to be associated with immune rejection in hepatocellular carcinoma (HCC), leading to primary resis...
Comparison of mapping techniques of different antibody epitopes
Comparison of mapping techniques of different antibody epitopes
2023-12-11
During antibody development, selecting the right antibody that binds to the correct epitope of an antigen is crucial for achieving optimal therapeutic efficacy and leveraging the d...