Polygenic proinflammatory cytokine IL6
Polygenic proinflammatory cytokine IL6
2023-11-09
Interleukin-6 is a multifactorial proinflammatory cytokine, a hemoglobin complex composed of IL-6, its receptor IL6R, and glycoprotein 130 (IL-6/ILL-6R/GP130). This complex complex...
The advent of the era of antibody coupled drug ADC
The advent of the era of antibody coupled drug ADC
2023-06-21
Over the past 30 years, antibody-based anti-cancer therapies have achieved considerable success. Antibody-drug conjugates ( ADCs), a complex and evolving class of drugs, are specif...
Literature share antibody sequences defined a new target for osteosarcoma CAR-T therapy
Literature share antibody sequences defined a new target for osteosarcoma CAR-T therapy
2023-06-13
Osteosarcoma (OS) remains a frustrating malignancy in children and young adults, with a dismal prognosis for metastatic and recurrent disease. Immunotherapy in OS is less promising...
Multiplexed selectivity screening of anti-GPCR antibodies
Multiplexed selectivity screening of anti-GPCR antibodies
2023-05-12
（DahlL,etal. SciAdv.2023）The G protein-coupled receptor (GPCR) superfamily is the largest family of human membrane proteins and drug targets, comprising approximately 750 memb...
Pyroptosis the GSDM family
Pyroptosis the GSDM family
2023-03-27
Members of the gasdermin (GSDM) family are widely expressed and may play tissue-specific roles. For 15 years, scientists have been trying to determine the structure and function of...
Known antibody sequence development again
Known antibody sequence development again
2023-03-15
Antibodies, also known as immunoglobulins (Ig), were first described in 1890. They are large, Y-shaped glycoproteins that the immune system uses to recognize and neutralize foreign...
Transport protein superfamily SLC
Transport protein superfamily SLC
2023-03-08
To survive and maintain normal function, cells must closely monitor and control intracellular substances. By allowing specific molecules such as metabolites and ions to pass throug...