The target of angiogenesis regulation is DLL4
The target of angiogenesis regulation is DLL4
2024-10-08
DLL4, short for delta-like protein 4, is a Notch ligand that participates in the Notch signaling pathway, activating NOTCH1 and NOTCH4. It is involved in angiogenesis and negativel...
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
2024-10-08
BackgroundCancer immunotherapy, represented by immune checkpoint inhibitors (ICIs), has reshaped the treatment paradigm for advanced non-small cell lung cancer and small cell lung ...
Autoimmune cancer testicular antigen NY-ESO-1
Autoimmune cancer testicular antigen NY-ESO-1
2024-09-26
NY-ESO-1, also known as CTA1B (CTAG1B), is an autoimmune cancer antigen presented on the cell surface by major histocompatibility complex class I molecules and exhibits restri...
The hepatocellular carcinoma marker GPC3
The hepatocellular carcinoma marker GPC3
2024-09-24
Glypican-3 (GPC3) is a member of the heparan sulfate (HS) proteoglycan family. Anchored to the cell membrane via phosphatidylinositol, it serves as a multifunctional co-receptor on...
The proinflammatory cytokine IL18
The proinflammatory cytokine IL18
2024-09-20
Interleukin 18 (IL18), a member of the IL-1 cytokine family, is a proinflammatory cytokine that induces IFNγ production and plays a crucial role in inflammation. It is primarily in...
The unique cadherin CDH17
The unique cadherin CDH17
2024-09-20
CDH17 is a cadherin protein belonging to a subclass of the 7D-cadherin family. Its primary function is cell-cell adhesion, which may be involved in tumorigenesis. The adhesion mech...
Improving Protein Expression, Stability, and Function with ProteinMPNN
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024-09-18
BackgroundNatural proteins are highly optimized for function but are often difficult to produce at scales suitable for biotechnological applications due to poor expression in heter...