CD19 CD20 antibody fusion IL-15 protein dual targeted therapy for B-cell malignancies
CD19 CD20 antibody fusion IL-15 protein dual targeted therapy for B-cell malignancies
2024-03-13
Background:Despite the progress made in cancer therapy with monoclonal antibodies, such as the CD20 antibody rituximab, there remains a pressing need to optimize the ability of suc...
CD14: The pattern recognition receptor for LPS
CD14: The pattern recognition receptor for LPS
2024-03-13
CD14 is best known as a pattern recognition receptor of the innate immune system, where it plays an important role in sensitizing cells to Gram-negative bacterial lipopolysaccharid...
Antibody engineering series bispecific antibody
Antibody engineering series bispecific antibody
2024-03-13
Background:Bispecific antibodies (BsAbs) recognize two distinct epitopes or antigens, targeting different targets in different molecular formats and mediating anti-cancer effects t...
Polyhedral aminopeptidase CD13
Polyhedral aminopeptidase CD13
2024-03-05
CD13 (aminopeptidase N, membrane alanyl aminopeptidase, APN, EC 3.4.11.2, and ANPEP) is a ubiquitously expressed protease with multiple functions. As an enzyme, CD13 regulates the ...
Proinflammatory cytokine IL-17
Proinflammatory cytokine IL-17
2024-03-04
IL17 is a highly versatile proinflammatory cytokine that is required for important physiological activities such as host immune defense, tissue repair, pathogenesis of inflammatory...
Tumor microenvironment regulator IL-8
Tumor microenvironment regulator IL-8
2024-02-28
Interleukin 8 (IL8) is a proinflammatory CXC chemokine (CXCL8) that promotes neutrophil chemotaxis and degranulation. This chemokine activates multiple intracellular signaling path...
The integrin family molecule CD11
The integrin family molecule CD11
2024-02-27
Integrins are heterodimeric transmembrane proteins composed of α and β subunits that bind to the typical extracellular matrix and often serve as receptors for activating signaling ...